HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-Fluoro-4-methoxybenzoyl)propionic acid → 1-(3-Fluoro-4-methoxyphenyl)-4-(octahydropyrido[1,2-a]pyrazin-2-yl)butane-1,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-Fluoro-4-methoxybenzoyl)propionic acid | HCID 67671 | — |
| Reactant | 1-[(Tert-butoxy)carbonyl]piperidine-2-carboxylic acid | HCID 581831 | — |
| Reactant | 1-(3,4-Dimethoxyphenyl)-4-((S)-hexahydropyrrolo[1,2-a]pyrazin-2-yl)butane-1,4-dione | HCID 24886334 | — |
| Product | 1-(3-Fluoro-4-methoxyphenyl)-4-(octahydropyrido[1,2-a]pyrazin-2-yl)butane-1,4-dione | HCID 22393141 | — |
Reaction Steps
12 mg of the title compound were prepared as described for 1-(3,4-dimethoxyphenyl)-4-((S)-hexahydropyrrolo[1,2-a]pyrazin-2-yl)butane-1,4-dione, using 1-(tert-butoxycarbonyl)piperidine 2 carboxylic acid instead of BOC-protected proline and 3-(4-methoxy-3-fluorobenzoyl)propanoic acid instead of 3-(3,4-dimethoxybenzoyl)propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186721B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-3bf9597dce7545c3a17b56e186f4e07f |
| Source note | uspto-grants-2007_03 |