HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrogen → 1-(2-Bromoethoxy)-2,4-difluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Ethanol, 2-(2,4-difluorophenoxy)- | HCID 18437003 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(2-Bromoethoxy)-2,4-difluorobenzene | HCID 23294261 | — |
Reaction Steps
To a cool solution 2-(2,4-difluoro-phenoxy)-ethanol (0.48 g, 2.77 mmol.) in CH2Cl2 (15 ml), triphenyl phosphine (1.3 g, 5 mmol)) was added. Carbon tetrabromide (1.65 g, 5 mmol.) in CH2Cl2 (3 ml) was added to the solution dropwise under N2. The solution was stirred for 30 minutes. EtOAc was added, then the solvent was evaporated under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186726B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-d2aed284c51e47ada2a87d9c5beb07e7 |
| Source note | uspto-grants-2007_03 |