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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 456442Generated: October 25, 2026

1-Methyl-2-piperidinemethanol → 4-[2-(1-Methyl-piperidin-2-ylmethoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/456442

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methyl-2-piperidinemethanolHCID 89394—
ReactantTert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylateHCID 11543684—
Product4-[2-(1-Methyl-piperidin-2-ylmethoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl esterHCID 69418314—

Reaction Steps

The title compound was prepared by using Mitsunobu condition from 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and 1-Methyl-2-piperidinemethanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07186715B2
Source datasetuspto-grants-2007_03
ORD IDord-6882952cccc8433fbeb85050b9f417b3
Source noteuspto-grants-2007_03