1-Ethyl-3-pyrrolidinol → 4-[2-(1-Ethyl-pyrrolidin-3-yloxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

HRID 456443Notes

Reaction equation

HRID 456443 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[OH:20])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:21]([N:23]1[CH2:27][CH2:26][CH:25](O)[CH2:24]1)[CH3:22]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH:25]2[CH2:26][CH2:27][N:23]([CH2:21][CH3:22])[CH2:24]2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 982031-Ethyl-3-pyrrolidinolHCID 11543684Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate

Product 1

HCID 694199224-[2-(1-Ethyl-pyrrolidin-3-yloxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Procedure

The title compound was prepared by using Mitsunobu condition from 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and 1-Ethyl-3-pyrrolidinol.

Sources & evidence

ORD record
ord-aa9ab5f9ce2a4c819df56d5abc504527
Source dataset
uspto-grants-2007_03
Patent number
US07186715B2

Reaction notes

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