1-(4-Hydroxypiperidin-1-yl)ethan-1-one → 4-[2-(1-Acetyl-piperidin-4-yloxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

HRID 456447Notes

Reaction equation

HRID 456447 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[OH:20])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O[CH:22]1[CH2:27][CH2:26][N:25]([C:28](=[O:30])[CH3:29])[CH2:24][CH2:23]1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH:22]2[CH2:27][CH2:26][N:25]([C:28](=[O:30])[CH3:29])[CH2:24][CH2:23]2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 107492911-(4-Hydroxypiperidin-1-yl)ethan-1-oneHCID 11543684Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate

Product 1

HCID 694190504-[2-(1-Acetyl-piperidin-4-yloxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Procedure

The title compound was prepared by using Mitsunobu condition from 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and 1-(4-Hydroxy-piperidin-1-yl)-ethanone.

Sources & evidence

ORD record
ord-caaf940c2945415089d371af3ae4be6e
Source dataset
uspto-grants-2007_03
Patent number
US07186715B2

Reaction notes

Loading…