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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 456448Generated: October 29, 2026

1-Pyrrolidineethanol → 4-[2-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/456448

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-PyrrolidineethanolHCID 76288—
ReactantTert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylateHCID 11543684—
Product4-[2-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl esterHCID 69422116—

Reaction Steps

The title compound was prepared by using Mitsunobu condition from 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and 2-hydroxyethyl pyrrolidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07186715B2
Source datasetuspto-grants-2007_03
ORD IDord-b86bc20d65904cc5b13e13092e0143fc
Source noteuspto-grants-2007_03