2-(4-(Methylsulfonyl)piperazin-1-yl)ethanol → 4-{2-[2-(4-Methanesulfonyl-piperazin-1-yl)-ethoxy]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

HRID 456453Notes

Reaction equation

HRID 456453 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[OH:20])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:21][S:22]([N:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32]O)[CH2:27][CH2:26]1)(=[O:24])=[O:23]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH2:32][CH2:31][N:28]2[CH2:29][CH2:30][N:25]([S:22]([CH3:21])(=[O:23])=[O:24])[CH2:26][CH2:27]2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27624262-(4-(Methylsulfonyl)piperazin-1-yl)ethanolHCID 11543684Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate

Product 1

HCID 694182624-{2-[2-(4-Methanesulfonyl-piperazin-1-yl)-ethoxy]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Procedure

The title compound was prepared by using Mitsunobu condition from 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and 2-(4-Methanesulfonyl-piperazin-1-yl)-ethanol.

Sources & evidence

ORD record
ord-4578da62c9244c3db8faab58c07848d6
Source dataset
uspto-grants-2007_03
Patent number
US07186715B2

Reaction notes

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