HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 69420852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate | HCID 11543684 | — |
| Reactant | HCID 53397682 | HCID 53397682 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69420852 | HCID 69420852 | 47.3% |
Reaction Steps
(3-Hydroxy-2-methyl-propyl)-carbamic acid benzyl ester (5.0 g, 24.0 mmol) was dissolved in THF (175 mL) at 0° C. 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (6.7 g, 24.0 mmol) and triphenylphosphine (7.6 g, 29.0 mmol) were added. Diisopropyl azodicarboxylate (5.75 mL, 29.0 mmol) was added dropwise, and the mixture was stirred overnight. The mixture was concentrated under reduced pressure and purified using silica gel chromatography (25% ethyl acetate in hexanes) to afford the title compound (5.33 g, 47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186715B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-a14c117b2d5448e68f3ebaa49c3e50fd |
| Source note | uspto-grants-2007_03 |