Acetaldehyde → HCID 69420096, compound

Participants

Reaction Conditions

Reaction Steps

4-[2-(2-Amino-propoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (0.35 g, 0.75 mmol) was dissolved in methanol (25 mL), and the reaction was cooled to 0° C. Acetaldehyde (0.363 g, 8.25 mmol) and sodium triacetoxyborohydride (0.795 g, 3.75 mmol) were added. A reflux condenser was fitted and the flask was stirred at r.t. for about 24 hours. The solution was extracted with diethyl ether (3×50 mL) and then concentrated under reduced pressure to afford the final compound (0.360 g, 90%).

Provenance & Evidence