Triethylamine → HCID 18436785, compound

Participants

Reaction Steps

To a solution of compound from Step 4 (175 mg, 0.5 mmol) and Et3N (210 uL, 1.5 mmol) in 5 mL of CH2Cl2 at 0° C. was added MsCl (41 uL, 0.53 mmol) at 10 uL increment until starting material was no longer present by TLC. The mixture was quenched with saturated aqueous sodium bicarbonate, diluted with EtOAc and washed with 1 M HCl, water and brine, which was then dried (Na2SO4), filtered and concentrated to afford about 155 mg (0.36 mmol, 73%) of N-boc-4-[2-(2-methanesulfonylamino-2-methyl-propoxy)-phenyl]-piperazine as a yellow solid. LRMS (electrospray): 428.1 [M+1].

Provenance & Evidence