反应详情

A mixture of triflate (b) (25 g, 81.2 mmol) and propylamine hydrochloride (47 g, 487 mmol) in pyridine (300 ml) was heated to reflux overnight. The mixture was evaporated to dryness, dissolved in 0.5M aqueous hydrochloric acid (400 ml) and extracted three times with dichloromethane. The aqueous phase was then basified with 40% aqueous sodium hydroxide solution and extracted twice with dichloromethane. Drying and evaporation afforded a buff coloured solid (13.0 g, 90%).

1. temperaturewas heated
2. temperatureto reflux overnight
3. customThe mixture was evaporated to dryness
4. dissolutiondissolved in 0.5M aqueous hydrochloric acid (400 ml)
5. extractionextracted three times with dichloromethane
6. extractionextracted twice with dichloromethane
7. customDrying
8. customevaporation