Thioglycolic Acid → HCID 11459551, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-fluoro-3-nitro-phenyl)ethanol [RN20274-69-5](1.1 g, 6 mmol), mercaptoacetic acid (0.61 g, 6.6 mmol), potassium carbonate (2.8 g, 20 mmol) and N,N-dimethylformamide (12 ml) was heated at 70° C. for 4 hours. The mixture was poured onto water (200 ml) and the aqueous phase was washed with ethyl acetate. The aqueous phase was then acidified with 1M aqueous hydrochloric acid and extracted three times with dichloromethane. The extracts were dried and evaporated to give an oil (0.92 g, 60%).

Provenance & Evidence