反应详情

温度

-10 °C

A solution of crude 6-oxiranyl-2,3-dihydro-benzo[1,4]dioxine (200 mg, 1.12 mmol) in diethyl ether (20 ml) was cooled at −10° C. A 10% solution of boron trifluoride diethyl etherate in diethyl ether (0.16 ml) was then added and the mixture was stirred for 10 minutes at −10° C. The reaction was quenched at this temperature by addition of a saturated aqueous solution of sodium bicarbonate (10 ml). The mixture was extracted twice with diethyl ether. The combined organic phases were washed with water, brine, then dried over magnesium sulfate and evaporated to give crude (2,3-dihydro-benzo[1,4]dioxin-6-yl)-acetaldehyde (191 mg, 95%).

1. customThe reaction was quenched at this temperature by addition of a saturated aqueous solution of sodium bicarbonate (10 ml)
2. extractionThe mixture was extracted twice with diethyl ether
3. washThe combined organic phases were washed with water, brine
4. dry with materialdried over magnesium sulfate
5. customevaporated