HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylonitrile → Ethyl 1-(2-cyanoethyl)piperidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | Piperidine-4-carboxylic acid ethyl ester (ethylisonipecotate) | HCID 86594498 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Ethyl 1-(2-cyanoethyl)piperidine-4-carboxylate | HCID 43084552 | 101.5% |
Reaction Steps
A solution of piperidine-4-carboxylic acid ethyl ester (ethylisonipecotate) (4.7 g, 30 mmol), acrylonitrile (1.7 g, 31 mmol) in isopropyl alcohol (30 ml) was stirred at room temperature for 15 hours, then evaporated to dryness to afford 1-(2-cyano-ethyl)-piperidine-4-carboxylic acid ethyl ester as an oil (6.4 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186730B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-7524ec68f1c04433b6e1f6aa8924b0bb |
| Source note | uspto-grants-2007_03 |