Sodium Hydroxide → 1-[2-(4-Fluoro-1H-benzoimidazol-2-yl)-ethyl]-piperidine-4-carboxylic acid

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Reaction Steps

A solution of (b) (2.0 g, 6.3 mmol), 1M aqueous sodium hydroxide solution (1.2 ml, 1.2 mmol) in ethanol (40 ml) was stirred at room temperature for 3 hours. After concentration, the residue was diluted with water and acidified with a saturated solution of potassium hydrogenosulfate to pH 5. The precipitated solid was filtered, washed with water and dried under vacuum to afford a foam (1.0 g, 54%).

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