Triethylamine → HCID 86591867, compound

Participants

Reaction Steps

Methanesulfonyl chloride (0.45 ml, 5.8 mmol) was added dropwise to an ice-cooled solution of 2-benzo[1,2,5]thiadiazol-5-yl-ethanol (c) (1.0 g, 5.5 mmol) and triethylamine (0.85 ml, 6 mmol) in dichloromethane (20 ml) The reaction mixture was allowed to warn to room temperature and stirred for 16 hours. The organic solution was washed with water, dried over magnesium sulfate and evaporated to dryness. The oily residue was triturated with diisopropyl ether. The solid was collected by filtration and dried to give methanesulfonic acid 2-benzo[1,2,5]thiadiazol-5-yl-ethyl ester (1.2 g, 78%) which was used without further purification in the next step.

Provenance & Evidence