Potassium Carbonate → 1-[2-Oxo-2-(3-oxo-3,4dihydro-2H-benzo[1,4]thiazin-6yl)-ethyl]-piperidine-4-carboxylic acid (6-methoxy-[1,5]naphthyridin 4yl)-amide oxalate

Participants

Reaction Steps

A mixture of piperidine (1f) (0.39 g) and potassium carbonate (0.2 g) in N,N-dimethylformamide (13 ml) was treated with (a) (0.33 g). After 7 hours the mixture was evaporated and the residue partitoned between ethyl acetate and saturated aqueous sodium bicarbonate solution. The organic extract was dried and evaporated to give a brown oil. Chromatography on silica eluting with a methanol/ethyl acetate gradient afforded the free base of the title compound as an oil (0.19 g).

Provenance & Evidence