HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-oxo-2,3-dihydro-1h-pyrido[2,3-b][1,4]thiazine-7-carboxylate | HCID 17981264 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid | HCID 21873692 | 95.2% |
Reaction Steps
A solution of the ester (b) (2.8 g) in tetrahydrofuran (50 ml) was treated with 1M sodium hydroxide (30 ml). After 2 hours the mixture was concentrated to near dryness and acidified with 2M hydrochloric acid. Filtration and washing with water afforded a solid (2.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186730B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-68acaac0b0434d49a8eb76b7ef41f9a3 |
| Source note | uspto-grants-2007_03 |