反应详情

A mixture of 5-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrrole-3-carboxylic acid (100 mg, 0.44 mmol) (from Example 11) and thionyl chloride (2M in DCM, 5 mL) was heated to reflux for 2 hours. The reaction was concentrated, the residue was then stirred with isobutyl amine (excess) in DCM at room temperature for 2 hours. The reaction was diluted with DCM, washed with water, dried and concentrated. The residue was purified on a silica gel column to give the titled compound as a white solid.

1. temperaturewas heated
2. temperatureto reflux for 2 hours
3. concentrationThe reaction was concentrated
4. additionThe reaction was diluted with DCM
5. washwashed with water
6. customdried
7. concentrationconcentrated
8. customThe residue was purified on a silica gel column