HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 456644Generated: October 29, 2026
Phenethylamine → HCID 178523144, compound
https://huagongshe.com/reaction/456644
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 178469891 | HCID 178469891 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178523144 | HCID 178523144 | — |
Reaction Steps
A mixture of 5-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrrole-3-carboxylic acid (50 mg, 0.22 mmol) (from Example 11), HOBt (74 mg, 2.5 eq.), EDAC (105 mg, 2.5 eq.), phenethylamine (106 mg, 4 eq.) and TEA (0.5 mL) in DMF (1 mL) was heated at 40° C. for overnight. The reaction was concentrated and purified on a silica gel column to give the titled compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07186716B2 |
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| Source dataset | uspto-grants-2007_03 |
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| ORD ID | ord-4c02ccdde9c74f538bb90ab2510b6a5e |
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| Source note | uspto-grants-2007_03 |
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