Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrole | HCID 8027 | — |
| Reactant | Benzoyl chloride, 2-chloro-5-nitro- | HCID 117637 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 18436869 | HCID 18436869 | 30% |
Reaction Steps
Aluminum chloride (2.6 g, 20 mmol) was added to a mixture of 2-chloro-5-nitro-benzoyl chloride (5 g, 20 mmol) and pyrrole (4 g, 30 mmol) in DCM (100 mL) at 0° C. The mixture was stirred at 0° C. for 30 mins. The reaction was diluted with ethyl acetate, washed with brine, water, NaHCO3, dried and concentrated. The residue was purified on a silica gel column to give 1.5 g (30%) of (2-chloro-5-nitro-phenyl)-(1H-pyrrol-2-yl)-methanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07186716B2 |
|---|
| Source dataset | uspto-grants-2007_03 |
|---|
| ORD ID | ord-84332fdb95f5497ca76d0acb14116523 |
|---|
| Source note | uspto-grants-2007_03 |
|---|
