351458-51-0 → 351456-35-4

HRID 456647Notes

Reaction equation

HRID 456647 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[C:13]1[NH:14][CH:15]=[CH:16][CH:17]=1)([O-])=O>C(O)C.[Pd]>[NH:14]1[CH:15]=[CH:16][CH:17]=[C:13]1[C:7]1[C:6]2[C:10](=[CH:11][CH:12]=[C:4]([NH2:1])[CH:5]=2)[NH:9][N:8]=1

Participants

4

Reactant 1

HCID 135409235351458-51-0

Product 1

HCID 135506487351456-35-4Yield 62.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

5-Nitro-3-(1H-pyrrol-2-yl)-1H-indazole (37 mg) (from Example 22) was hydrogenated using 5% Pd/C (20 mg) in ethanol (5 mL) for 2 hours. The reaction was filtered and the filtrate was concentrated to give 20 mg of the titled compound.

Workup

  1. customfor 2 hours
  2. filtrationThe reaction was filtered
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-87046f4411624b4d98d508f153afedcb
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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