反应详情

温度

50 °C

Into a 100-mL 3-necked round-bottom flask, was placed a solution of N-(4-acetylphenyl)acetamide (1 g, 5.65 mmol, 1.00 equiv) in acetic acid (10 mL). This was followed by the addition of a solution of bromine (910 mg, 5.69 mmol, 1.01 equiv) in acetic acid (2 mL) dropwise with stirring at 50° C. The resulting solution was stirred for 1.5 h at 50° C. The reaction was then quenched by the addition of 100 mL of water/ice. The solids were collected by filtration and dried under vacuum. This resulted in 0.5 g (33%) of N-(4-(2-bromoacetyl)phenyl)acetamide as a white solid.

1. customInto a 100-mL 3-necked round-bottom flask, was placed
2. stirringThe resulting solution was stirred for 1.5 h at 50° C
3. customThe reaction was then quenched by the addition of 100 mL of water/ice
4. filtrationThe solids were collected by filtration
5. customdried under vacuum
6. customThis resulted in 0.5 g (33%) of N-(4-(2-bromoacetyl)phenyl)acetamide as a white solid