Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | HCID 135401118 | HCID 135401118 | — |
| Catalyst | Methylhydrazine | HCID 6061 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 135464264 | HCID 135464264 | — |
Reaction Steps
A mixture of 5-(2-chloro-5-nitro-benzoyl)-1H-pyrrole-2-carboxylic acid (3-fluoro-phenyl)-amide (250 mg, 0.6 mmol) (Example 47), methyl hydrazine (4 drops), toluene (0.6 mL) and 1-methyl-pyrrolin-2-one (0.2 mL) was heated at 120° C. for 2 hours. The reaction was concentrated, triturated with DCM and hexane to give 55 mg of the titled compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07186716B2 |
|---|
| Source dataset | uspto-grants-2007_03 |
|---|
| ORD ID | ord-4eb405362d0c470d8923479e38e75084 |
|---|
| Source note | uspto-grants-2007_03 |
|---|
