Tin tetrachloride → HCID 85934579, compound

Participants

Reaction Steps

To a mixture of 1H-pyrrole-2-carboxylic acid (3-fluoro-phenyl)-amide (930 mg, 4.6 mmol) (Example 47) and 2,4-difluoro-benzoyl chloride (1.3 g, 7.4 mmol) in benzene (10 mL) at room temperature, was added a solution of tin (IV) chloride (1.5 mL). After stirring at room temperature for overnight and the usual work-up, the residue was purified on a silica gel column to give 180 mg of 5-(2,4-difluoro-benzoyl)-1H-pyrrole-2-carboxylic acid (3-fluoro-phenyl)-amide.

Provenance & Evidence