HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 456673Generated: October 29, 2026
N-methyl-2-pyrrolidone → 5-(5-Trifluoromethyl-1H-indazol-3-yl)-1H-pyrrole-2-carboxylic Acid (3-fluoro-phenyl)-amide
https://huagongshe.com/reaction/456673
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 5-(2-fluoro-5-trifluoromethyl-benzoyl)-1H-pyrrole-2-carboxylic acid (3-fluoro-phenyl)-amide | HCID 86592249 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-(5-Trifluoromethyl-1H-indazol-3-yl)-1H-pyrrole-2-carboxylic Acid (3-fluoro-phenyl)-amide | HCID 135531225 | — |
Reaction Steps
A mixture of 5-(2-fluoro-5-trifluoromethyl-benzoyl)-1H-pyrrole-2-carboxylic acid (3-fluoro-phenyl)-amide, hydrazine hydrate, 1-methyl-pyrrolin-2-one and toluene was heated at 120° C. for 2 hours. The reaction was concentrated, mixed with water and filtered. The solid was washed to give the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07186716B2 |
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| Source dataset | uspto-grants-2007_03 |
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| ORD ID | ord-180617e1467c48e5a7ed62a973f3bfca |
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| Source note | uspto-grants-2007_03 |
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