Ammonium Hydroxide → HCID 10184407, compound

Participants

Reaction Steps

In a similar manner as described in Example 28 from 4-{8-(cyclopentylamino)-3-[2-(cyclopentylamino)-4-pyrimidinyl]imidazo[1,2-α]pyridin-2-yl}benzonitrile (15 mg, 0.03 mmol), ammonium hydroxide, and hydrogen peroxide in tetrahydrofuran/methanol was formed 4-{8-(cyclopentylamino)-3-[2-(cyclopentylamino)-4-pyrimidinyl]imidazo[1,2-α]pyridin-2-yl}benzamide (8 mg, 52%) as a yellow solid. 1H NMR (CDCl3): δ 8.76 (broad, 1H), 8.12 (d, 1H), 7.88 (d, 2H), 7.81 (d, 2H), 6.82 (t, 1H), 6.40 (d, 1H), 6.31 (d, 1H), 5.27 (m, 2H), 4.38 (m, 1H), 3.97 (m, 1H), 2.19–2.10 (m, 4H), 1.84–1.58 (m, 12H); MS m/z 482 (M+1).

Provenance & Evidence