Dimethylformamide → HCID 82060381, compound

Participants

Reaction Steps

6,8-Dichloro-2-(4-fluorophenyl)imidazo[1,2-α]pyridine (6 g, 0.021 moles) was treated with phosphorous oxychloride (3.0 mL, 33 mmol) in N,N-dimethylformamide in a similar manner as described in Example 2 to give 6,8-dichloro-2-(4-fluorophenyl)imidazo[1,2-α]pyridine-3-carbaldehyde (4.9 g, 75%) as a white solid. 1H NMR (CDCl3): δ 10.05 (s, 1H), 9.69 (d, 1H), 7.86 (q, 2H), 7.65 (d, 1H), 7.25 (t, 2H); 19F NMR (CDCl3) δ −110.3; MS m/z 309 (M+1).

Provenance & Evidence