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HRID456725

反应详情

EQUATION

反应方程式

HRID 456725 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N1[C@H](C(=O)N2CCC[C@H]2C#N)[C@@H]2CC[C@H]1[C@@H](O)[C@H]2O
HCID86598887

未命名化合物

PRODUCTS

生成物

1
结构：Cl.N#C[C@@H]1CCCN1C(=O)[C@H]1N[C@H]2CC[C@@H]1[C@H](O)[C@@H]2O
HCID11197388

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

To a solution of tert-butyl (1S,3S,4S,5S,6R)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-5,6-dihydroxy-2-azabicyclo[2.2.2]octane-2-carboxylate obtained in Example 1-4 (122 mg) in chloroform (1 mL), was added 4N HCl in dioxane (3 mL) at room temperature. The reaction mixture was stirred for 15 minutes and the organic solvent was removed in vacuo. The residue was triturated with ethyl acetate to give the target compound as a white powder (100 mg).

WORKUP

后处理

  1. customthe organic solvent was removed in vacuo
  2. customThe residue was triturated with ethyl acetate