HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-Chloro-N-(4-methyltetrahydro-2H-pyran-4-yl) acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | 4-Methyloxan-4-ol | HCID 12347118 | — |
| Product | 2-Chloro-N-(4-methyltetrahydro-2H-pyran-4-yl) acetamide | HCID 18437326 | — |
Reaction Steps
To a solution of 4-methyltetrahydro-2H-pyran-4-ol obtained in Example 7-1 in chloroacetonitrile (0.65 mL), was added a mixture of acetic acid and conc. sulfuric acid (1/1, 1.6 mL) dropwise with cooling on an ice bath. The reaction mixture was warmed to room temperature and stirred for 3 hrs.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186731B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-194497308cdf495f949142f79cca5feb |
| Source note | uspto-grants-2007_03 |