HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-piperidone → 1-Benzyl-4-methylpiperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-piperidone | HCID 19220 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Benzyl-4-methylpiperidin-4-ol | HCID 10845913 | — |
Reaction Steps
Under nitrogen atmosphere, methylmagnesium bromide (3.0M solution in diethyl ether, 10.8 mL) was diluted with tetrahydrofuran (110 mL) with cooling on an ice bath. To the solution, was added dropwise a solution of 1-benzyl-4-piperidinone (5.6 g) in tetrahydrofuran (40 mL), and the mixture was stirred for 1 hr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186731B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-7b5e29e25b744775b2131ce49df9c7c5 |
| Source note | uspto-grants-2007_03 |