Pyrrolidine → HCID 86598897, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (1R,3S,4S,6R)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-6-[(methylsulfonyl) oxy]-2-azabicyclo[2.2.1]heptane-2-carboxylate obtained in Example 12-1 (153 mg) in dimethylformamide (2.0 mL), was added pyrrolidine (79 mg). The mixture was stirred at 80° C. for 1 hr. The resulting mixture was evaporated in vacuo and the residue was chromatographed on silica gel eluting with chloroform and methanol (19:1) to give the target compound (91 mg).

Provenance & Evidence