Ammonium Chloride → HCID 86598901, compound

Participants

Reaction Steps

To 2-tert-butyl 3-methyl (1R,3S,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate (3.04 g), was added 1N sodiummethoxide solution in methanol (34 mL). The mixture was stirred at reflux for 4 hrs. To the resulting mixture was added ammonium chloride solution and evaporated in vacuo. Water was added to the residue, and the mixture was extracted with ethyl acetate. The combined organic phase was washed with brine, dried over sodium sulfate, and evaporated in vacuo. The residue was recrystalized from hexane-diethyl ether to give the target compound (1.09 g) as a solid.

Provenance & Evidence