Lithium hydroxide, monohydrate → HCID 69134660, compound

Participants

Reaction Steps

To a solution of tert-butyl (1R,3S,4S,6R)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-6-(2-ethoxy-2-oxoethoxy)-2-azabicyclo[2.2.1]heptane-2-carboxylate obtained in Example 15-1 (249 mg) in dioxane (3 mL) and water (1 mL), was added lithium hydroxide monohydrate (302 mg). The mixture was stirred at room temperature for 1 hr. The resulting mixture was evaporated in vacuo. 1N Hydrochloric acid (1.2 mL) was added to the residue, and the mixture was extracted with ethyl acetate. The combined organic phase was washed with brine, dried over sodium sulfate, and evaporated in vacuo to give the target compound (261 mg).

Provenance & Evidence