Citric Acid → HCID 86598911, compound

Participants

Reaction Steps

To a solution of tert-butyl (1R,3S,4S,6R)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-6-(2-oxoethoxy)-2-azabicyclo[2.2.1]heptane-2-carboxylate obtained in Example 25-1 (238 mg) in methanol (6 mL), was added sodium borohydride (26.2 mg). The mixture was stirred at room temperature for 20 minutes. To the resulting mixture, was added citric acid solution. The mixture evaporated in vacuo. The residue was diluted with ethyl acetate, and washed with water and brine. The organic phase was dried over sodium sulfate and evaporated in vacuo to give the target compound (220 mg).

Provenance & Evidence