Methanesulfonyl chloride → HCID 86598913, compound

Participants

Reaction Steps

To a solution of 2-tert-butyl 3-methyl (1R,3S,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate (185 mg) in pyridine (2 mL), was added methanesulfonyl chloride (117 mg). The mixture was stirred at room temperature for 2 hrs. The resulting mixture was evaporated in vacuo. To the residue, water was added. The mixture was extracted with ethyl acetate. The combined organic phase was washed with brine, dried over sodium sulfate, and evaporated in vacuo. The residue was chromatographed on silica gel eluting with hexane and ethyl acetate (1:1) to give the target compound (237 mg).

Provenance & Evidence