HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentadiene → Methyl (1S,3S,4R)-2-((1R)-1-phenylethyl)-2-azabicyclo(2.2.1)hept-5-ene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentadiene | HCID 7612 | — |
| Reactant | 3,3,3-Trifluoropropionic acid | HCID 2777972 | — |
| Reactant | HCID 178501625 | HCID 178501625 | — |
| Solvent | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Product | Methyl (1S,3S,4R)-2-((1R)-1-phenylethyl)-2-azabicyclo(2.2.1)hept-5-ene-3-carboxylate | HCID 11780161 | — |
Reaction Steps
To a solution of methyl (2Z)-{[(1R)-1-phenylethyl]imino}acetate obtained in Example 42-1 (238 g) in 2,2,2-trifluoroethanol, was added trifluoromethylacetic acid (95.9 mL) at −10° C. The mixture was then stirred at the same temperature. After 1 hr, cyclopentadiene was added dropwise at −10° C. over 30 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186731B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-7dd52d3492074254a2cb18f041a15926 |
| Source note | uspto-grants-2007_03 |