反应详情

In a similar manner as described in step 4 of Example 1, the title compound was prepared from 1-(6-methoxy-2-naphthyl)-4-phenylbutane-1,4-dione (0.300 g, 0.942 mmol), prepared in step 3 of Example 1, and benzyl amine (0.121 g, 1.13 mmol). The crude material was dissolved in methylene chloride and filtered through silica gel (95 g, 200–300 mesh). The solvent was removed under reduced pressure to give 1-benzyl-2-(6-methoxy-2-naphthyl)-5-phenyl-1H-pyrrole as a white solid (0.32 g, 87%), mp 152–153° C. Elemental Analysis for C28H23NO Calc'd: C, 86.34; H, 5.95; N, 3.60. Found: C, 85.46; H, 6.06; N, 3.58.

1. filtrationfiltered through silica gel (95 g, 200–300 mesh)
2. customThe solvent was removed under reduced pressure