反应详情

In a similar manner as described in step 2 of Example 3, the title compound was prepared from {[6-(1-methyl-5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}acetonitrile (0.20 g, 0.48 mmol), prepared in the previous step, ammonium chloride (0.077 g, 1.44 mmol) and sodium azide (0.094 g, 1.44 mmol) in DMF (10 mL). The precipitated solids were isolated by vacuum filtration to give 5-({[6-(1-methyl-5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}methyl)-1H-tetraazole. as a white solid (0.228 g, 81%), mp 231–233° C. (dec). Elemental Analysis for C23H19N5O.0.34 H2O.0.07 C3H7NO Calc'd: C, 70.99; H, 5.18; N, 18.08. Found: C, 70.84; H, 5.07; N, 18.18.

1. customThe precipitated solids were isolated by vacuum filtration