反应详情

温度

205 °C

In a similar manner as described in step 5 of Example 1, the title compound was prepared from 2-(6-methoxy-2-naphthyl)-1,5-dipheny-1H-pyrrol (1.25 g, 3.33 mmol), prepared in the previous step, and pyridine hydrochloride (30 g) with the exception that this reaction required heating at 205° C. Purification on silica gel (500 g, 200–300 mesh) using methylene chloride as the eluent gave 6-(1,5-diphenyl-1H-pyrrol-2-yl)-2-naphthol as a reddish solid (1.00 g, 83%), mp 222–223° C. Elemental Analysis for C26H19NO.0.11 C4H8O2 Calc'd: C, 85.57; H, 5.40; N, 3.77. Found: C, 85.28; H, 5.53; N, 3.73.

1. customPurification on silica gel (500 g, 200–300 mesh)