Sodium Hydroxide → HCID 11635852, compound

Participants

Reaction Steps

A mixture of dimethyl 4-{[(6-{5-phenyl-1-[4-(trifluoromethyl)benzyl]-1H-pyrrol-2-yl}-2-naphthyl)oxy]methyl}isophthalate (165 mg, 0.254 mmol), prepared in the previous step, and 1 N NaOH (1.52 mL, 1.52 mmol) in 30 mL of THF plus 20 mL of methanol plus 5 mL of water was refluxed under nitrogen for 6 h. The reaction was filtered, cooled to room temperature, acidified by the addition of 5 mL of 1 N HCl and then concentrated under reduced pressure to remove the THF and methanol. The solid present was collected by filtration, rinsed with water and dried under reduced pressure at 60° C. to give the title compound (148 mg, 94%) as a yellow solid, mp 250–252° C. Elemental Analysis for C37H26F3NO5.0.18 C4H8O.0.34 H2O Calc'd: C, 70.71; H, 4.42; N, 2.19. Found: C, 70.65; H, 4.34; N, 2.13.

Provenance & Evidence