反应详情

A mixture of 2-chloro-5-trimethylsilanylethynyl-benzoic acid methyl ester (3.2 g, 12 mmol) in formic acid (50 mL) was heated at reflux for 16 h. The mixture was cooled to room temperature and concentrated in vacuo. The residue was diluted with ethyl acetate and washed with saturated aqueous sodium bicarbonate, water and brine. The organic layer was dried, filtered and concentrated in vacuo to afford the title compound (1.4 g).

1. temperaturewas heated
2. temperatureat reflux for 16 h
3. concentrationconcentrated in vacuo
4. additionThe residue was diluted with ethyl acetate
5. washwashed with saturated aqueous sodium bicarbonate, water and brine
6. customThe organic layer was dried
7. filtrationfiltered
8. concentrationconcentrated in vacuo