Nitrogen → HCID 18439222, compound

Participants

Reaction Steps

In a 3-neck 250 mL round-bottom flask fitted with a thermometer and a condenser, 3-methoxy-2,4,6-triiodobenzoic acid (10.38 g) was dissolved in a 2:1 mixture of Et2O and methanol at 0° C. A 2.0 M hexanes solution of TMSCHN2 was added dropwise until yellow color persisted and N2 bubbling stopped. The reaction mixture was stirred for 30 minutes and quenched with glacial acetic acid. Solvents and excess AcOH were removed in vacuo for 18 h to give the desired ester as a white solid which was used in the next step without any further purification. Yield 11.07 g (˜100% crude).

Provenance & Evidence