HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → 1-(3-Chloropropoxy)-4-iodobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | 4-Iodophenol | HCID 10894 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-(3-Chloropropoxy)-4-iodobenzene | HCID 15895520 | — |
Reaction Steps
A suspension of 4-iodophenol (20 g), 1-bromo-3-chloropropane (18 mL), and potassium carbonate (38 g) in acetone (250 mL) was heated at reflux for 16 h and allowed to cool to room temperature. The suspension was filtered, and the filtrate was evaporated in vacuo. Kugelrohr distillation of the residue (5–10 mm Hg, 210° C.) gave the title compound as a white crystalline solid (22 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186732B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-f9e4d54f261e497eb9249211666bb8be |
| Source note | uspto-grants-2007_03 |