HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-Chloropropyl 4-(piperidinomethyl)phenyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-(3-Chloropropoxy)-benzaldehyde | HCID 3551479 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Chloropropyl 4-(piperidinomethyl)phenyl ether | HCID 4365932 | — |
Reaction Steps
A solution of the product of Example 11 (5.0 g), piperidine (3.1 mL), and acetic acid (2.0 mL) in DCE (100 mL) was treated with sodium triacetoxyborohydride (9.3 g). After 16 h, the resulting mixture was diluted with water (100 mL) and extracted with DCM (3×50 mL). The combined organic phases were dried (magnesium sulfate) and evaporated, giving the title compound as an amber oil (5.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186732B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-d3819a0f4ecc4f77837417e325b4ef5c |
| Source note | uspto-grants-2007_03 |