HuagongsheHuagongshe Chemistry Print Report · For research reference only
Donepezil Oxalate → Donepezil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Donepezil Oxalate | HCID 11397232 | — |
| Solvent | Water | HCID 962 | — |
| Product | Donepezil | HCID 3152 | — |
Reaction Steps
Donepezil oxalate is dissolved in water and basified. Donepezil base thus obtained, is extracted in a suitable solvent and acidified with aqueous hydrochloric acid. The solvent is evaporated and aqueous acidic solution of Donepezil hydrochloride is lyophilized to obtain Donepezil hydrochloride amorphous form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186842B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-89100b8d2c32439cb682a641e143944c |
| Source note | uspto-grants-2007_03 |