HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Bromo-6-methoxy-2-methylthioquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Bromo-2-methanesulfonyl-6-methoxy-quinoline | HCID 22139732 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Bromo-6-methoxy-2-methylthioquinoline | HCID 22139696 | — |
Reaction Steps
The 5-bromo-2-methanesulfonyl-6-methoxy-quinoline was dissolved in 20 mL DMF and treated with 3 eq NaSCH3. After stirring 1 hour at room temperature the mixture was poured into water and extracted with ether. The crystalline product, 5-bromo-6-methoxy-2-methylsulfanyl-quinoline, was isolated in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186840B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-8542729a995243a999855b2982dc87ae |
| Source note | uspto-grants-2007_03 |