反应详情

温度

80 °C

To a solution of 3,5-dibromo-imidazo[1,2-a]pyrazine (D) (400 mg, 1.44 mmol) in dioxane (2 ml) was added ethanolamine (0.436 ml, 7.22 mmol). The mixture was heated at 80° C. in sealed tube for 5 hr. The mixture was then cooled to rt, diluted with 20% IPA/DCM and water. The organic layer was washed with brine, dried and concentrated. The residue was purified on a silica gel column to give 124 mg (yield 33%) of the title compound.

1. temperatureThe mixture was then cooled to rt
2. washThe organic layer was washed with brine
3. customdried
4. concentrationconcentrated
5. customThe residue was purified on a silica gel column