Potassium Carbonate → 5-(4-Fluorophenyl)-N-methylimidazo[1,2-a]pyrazin-8-amine

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	4-Fluorophenylboronic acid	HCID 285645	—
Reactant	5-Bromo-N-methylimidazo[1,2-a]pyrazin-8-amine	HCID 58777792	—
Catalyst	HCID 178418397	HCID 178418397	—
Solvent	Water	HCID 962	—
Solvent	Dimethylformamide	HCID 6228	—
Product	5-(4-Fluorophenyl)-N-methylimidazo[1,2-a]pyrazin-8-amine	HCID 58777806	—

Reaction Conditions

Temperature	170 °C

Reaction Steps

To a solution of (5-bromo-imidazo[1,2-a]pyrazin-8-yl)-methyl-amine (intermediate O) (68 mg, 0.3 mmol) in DMF (4 ml) and water (2 ml) was added 4-fluorobenzene boronic acid (84 mg, 0.6 mmol), K2CO3 (165 mg 1.2 mmol), and Pd(PPh3)4 (35 mg, 0.1 eq). The mixture was heated at 170° C. in microwave for 6 min. The mixture was purified on a silica gel column to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07186832B2
Source dataset	uspto-grants-2007_03
ORD ID	ord-3399e78dd7f541789377281cb704872e
Source note	uspto-grants-2007_03