Sodium Hydroxide → HCID 66758567, compound

HRID 457036Notes

Reaction equation

HRID 457036 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:39])[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH:16]=[C:17]3[C:27]4[C:22](=[N:23][CH:24]=[CH:25][CH:26]=4)[O:21][C:20]4[CH:28]=[CH:29][CH:30]=[C:31]([O:32][CH2:33][C:34]([O:36]CC)=[O:35])[C:19]=4[CH2:18]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[C:34]([CH2:33][O:32][C:31]1[C:19]2[CH2:18][C:17](=[CH:16][CH2:15][CH2:14][N:11]3[CH2:10][CH2:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)([OH:39])[CH2:13][CH2:12]3)[C:27]3[C:22]([O:21][C:20]=2[CH:28]=[CH:29][CH:30]=1)=[N:23][CH:24]=[CH:25][CH:26]=3)([OH:36])=[O:35]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66758249HCID 66758249, compound

Product 1

HCID 66758567HCID 66758567, compoundYield 91.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of product of example 48 (3.0 g) in methanol (50 ml) was added 1N sodium hydroxide solution (8 ml) and the mixture stirred at room temperature for 1 hour. The reaction mixture was distilled off under reduced pressure. The residue was dissolved with water and neutralized with 1N hydrochloric acid. The precipitation was filtered and washed with water to give the titled compound (2.6 g).

Workup

  1. distillationThe reaction mixture was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved with water and neutralized with 1N hydrochloric acid
  3. customThe precipitation
  4. filtrationwas filtered
  5. washwashed with water

Sources & evidence

ORD record
ord-749153c7212f4fcaa6a8459fc402feb6
Source dataset
uspto-grants-2007_03
Patent number
US07186729B2

Reaction notes

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