反应详情

To a solution of product of example 48 (3.0 g) in methanol (50 ml) was added 1N sodium hydroxide solution (8 ml) and the mixture stirred at room temperature for 1 hour. The reaction mixture was distilled off under reduced pressure. The residue was dissolved with water and neutralized with 1N hydrochloric acid. The precipitation was filtered and washed with water to give the titled compound (2.6 g).

1. distillationThe reaction mixture was distilled off under reduced pressure
2. dissolutionThe residue was dissolved with water and neutralized with 1N hydrochloric acid
3. customThe precipitation
4. filtrationwas filtered
5. washwashed with water